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E. H. Kerns

Drug-Like Properties, 2nd ed.

Autor: Kolektiv autorů - Di, L. , Kerns, E. H.

publisher: Elsevier Books

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Of the thousands of novel compounds that a drug discovery project team invents and that bind to the therapeutic target, only a fraction have sufficient ADME (absorption, distribution, metabolism, elimination) properties, and acceptable toxicology properties, to become a drug product that will successfully complete human Phase I clinical trials. Drug-Like Properties: Concepts, Structure Design and

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